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Research activities
AICTE funded project
TITLE  - Development of natural and semi-synthetic hit molecule and their formulation in tuberculosis

Duration  – 2 years

Principal investigator     : Dr. Y. Padmanabha Reddy, Ph. D

Co-Pricipal investigator : Dr. P. Ramalingam, Ph. D

Research Directors in Campus
Name of Research Guide  available in the Institution Recognized by Number of Research Scholar Registered Research paper Publications Conferences Attended
Dr. Y. Padmanabha Reddy, M.Pharm, Ph.D, F.I.C JNT University, Hyderabad, AP,

JNT University, Anantapur, AP

Acharya Nagarjuna University, Guntur, AP

 
12
 
27
 
45
Dr. J. Ravindra Reddy, M.Pharm, Ph.D JNT University, Anantapur, AP 07 16 36
Dr. C. Sowmya, M.Pharm, Ph.D JNT University, Anantapur, AP 01 14 18
Dr.P.Ramalingam, M.Pharm, Ph.D JNT University, Anantapur, AP 01 43 25
 
Downloads
About_the_Journal.pdf
Issue, Vol. 1, 2012
Instruction_for_Author_and_manuscript_submission.pdf
Research Focus
  1 Synthesis of Newer heterocyclic compounds and evaluation for their Antimicrobial, Anti- tubercular activity, Anti-inflammatory, Analgesic, Anticonvulsant, Sedative etc.
  2 QSAR study of series for their biological activity (Chem Draw ultra 8.0, MM2, MOPAC server, VALSTAT)
  3 Pharmacognostical study of Medicinal plants
  4 Pharmacological screening of Plant extract for following potential
   
  Nephrotoxicity
  Antidiabetic
  Antioxidants
  Antiosteoporasis
  Antidepressants
  Anticonvulsants
  Hepatoprotective
  Wound Healing
  5 Preformulation studies
  6 Development and evaluation of New NDDS
  7 RP-HPLC Method development and Validation by ICH/USP Guidelines
  8 Stability Indicating Assay by RP-HPLC Mehods
  9 Bioanalytical and bioequivalence study by RP-HPLC methods 
 
Publication and Presentations Related to the Institutions:
  Visible spectrophotometric determination of Ceftriaxone Asian Journal of Chemistry, 13, p.1643,2001.
  New spectrophotometric methods for the determination of Silymarin Acta Ciencia Indica, 27, p.83,2001.
  Spectrophotometric determination of Cefuroxime Sodium in pharmaceutical dosage forms   Antiseptic,99,88,2002. 4. Spectrophotometric determination of Silymarin
  Asian journal of Chemistry, 13,p,1234,2001.
  Assay of Venlafaxine hydrochloride in bulk samples and pharmaceutical formulations by    Extractive Spectrophotometry    International journal of Chemical Sciences,4(1),p.151-156,200
  Extractive Spectrophotometric methods for the determination of Clarithromycin Acta Ciencia Indica, 2002,28(c),41-44.
  Visible Spectrophotometric determination of Cefuroxime Sodium  Asian Journal of Chemistry,Vol.13.No.4(2001),1643-1645.
  Qualitative determination of Thalidomide using RP-HPLC Int. Journal of chemical Sciences,5(2),2007,743-748.
  Qualitative determination of Nevirapine in Pharmaceutical dosage forms by RP-HPLC Int. Journal of chemical sciences,6(1),2008,417-421.
  Antimicrobial activity of seeds of Abrus precatorius Linn Asian Journal of chemistry, Vol.21,No.2(2009),1630-1632
  Spectrophotometric Estimation of Ofloxacin in Pure and Pharmaceutical Dosage Forms Asian Journal of chemistry, Vol.21,No.3(2009),2473-2475
  Evaluation of Anti-Inflammatory activity of Acalypha Indica The Indian Pharmacist-Vol.VII,No.75,89-91.
  Permeation studies of Glipizide from Ficus caria fruit mucilage matrices for transdermal delivery  Biomed -4(1) Jan-Mar 2009, pp 70-75.
  Fabrication and evaluation of Aloe barbadensis Miller mucilage based sustained release matrix  Tablets of Glipizide. Biomed -4(2) April-June 2009, pp 192-197.
  Fabrication and evaluation of Aloe barbadensis Miller mucilage based sustained release matrix Tablets of Glimepiride. Asian Journal of Chemistry,Vol.21.No.8(2009),6271-6276.
  Synthesis and Antimicrobial Evaluation of Dibenzo (B,E) Azepin-5,10-(1H) Diones/ 10-substituted Dibenzo (B,E) Azepines.   International Journal of Pharmaceutical Research and Development – Online.
  Spectrophotometric method for the Evaluation of Glimepiride in bulk and pharmaceutical  Formulations. Internatinal journal of Chemical Sciences, 7(3), 2009,1624-1628.
  Preliminary phyotochemical investigation and cytotoxicity studies on the roots of Coccinia grandis linn. – Paper presented during 61st IPC, Ahmedabad.
  Synthesis and antimicrobial evaluation of Dibenzo (B,E) azepin-5,10-(1H)Diones/10-substituted dibenzo (B,E) azepines - Paper presented during 61st IPC, Ahmedabad.
  Review: Polymers in colon drug targeting.      Indian Drugs, 47(3),March 2010,5-13.
  Effect of Leucas aspera on Lead Acetate Induced Nephrotoxicity in Rats,     Asian Journal of Chemistry, vol.22,No.3(2010),2450-2452.
  Vitro Protein Binding Study of Ciprofloxacin by New UV-Spectrophotometric Method.      International Journal of Pharm Tech Research, vol.2,No.2,pp1150-1154.
  In vitro antitubercular and antimicrobial activity of 1- substituted quinoxaline–2, 3(1H, 4H)–diones. Bioorganic & Medicinal chemistry letter accepted –BMCL -14973)
  Synthesis And Antimicrobial Evaluation Of  Dibenzo (b,e ) Azepin - 5, 10 - (1h)Diones/   10 - Substituted  Dibenzo (b,e) Azepines, Int. journal. Pharm research and development, Volume - 1 / Issue - 9 / Article No - 11 (online).
  Cheimanipulation approch at Pharmacophore of Nalidixic acid by Michael addition, Acta ciencia indica (International Journal of Physical Sciences). XXXI C, No.3, 129 (2005).
  Synthesis of some new coumarino [4,3-b]pyrido [6,5-c] cinnolines as potent antitubercular agents, Indian journal of Heterocyclic chemistry (International Journal), vol.15, April – June,  P.no . 359 – 362, (2006).
  A Molecular manipulation approach at Pharmacophore of Nalidixic acid., Acta ciencia indica (International Journal of Physical Sciences). XXXII C, No.4, 335 (2006).
  Comparative Study on oral and Transdermal Administration of ditiazem Hydrochloride in Rabbits., The Pharma Review., Aug’ - 149-151, (2006).
  Impact of 4-Thiazolidinones and 2-Azetidinones on Antimicrobial spectrum of Nalidixic acid., Acta ciencia indica (International Journal of Physical Sciences). XXXII C, No.4, 433 (2006).
  Synthesis and Anti Microbial evaluation of Some Schiff bases of 4-Oxo-Quinolino(2,3-c) Pyridines., Acta ciencia indica (International Journal of Physical Sciences). XXXII C, No.4, 363 (2006).
  Simultaneous Spectrometric Estimation and validation of Cefixime and ornidazole in bulk and pharmaceutical dosage forms by absorbance ratio method (Q – Analysis) Acta ciencia indica (International Journal of Physical Sciences). XXXIII C, No.3, 267 (2007).
  Visible Spectroscopic Estimation and validation of Cefpodoxime proxetil in Bulk and Pharmaceutical Dosage Forms., Asian Journal of Chemistry. Vol.20, No.5(2008), 3373 – 3376.
  Visible Spectroscopic Estimation and validation of Ornidazole in Bulk and Pharmaceutical Dosage Forms., Asian Journal of Chemistry. Vol.20, No. 5 (2008), 3377 – 3380.
  Spectrophotometric Determination and validation of Cefriaxone sodium in bulk and pharmaceutical dosage forms Acta ciencia indica (International Journal of Physical Sciences). XXXIV C, No.3, 547 (2008).
  Spectrophotometric Determination and validation of Sparfloxacin in bulk and pharmaceutical dosage forms Acta ciencia indica (International Journal of Physical Sciences). XXXIV C, No.3, 423 (2008).
  Spectrophotometric Determination and validation of Aceclofenac in bulk and pharmaceutical dosage forms Acta ciencia indica (International Journal of Physical Sciences). XXXIV C, No.3, 447 (2008).
 
Paper Presented in International/ National Conferences
  Evaluation of newly synthesized cinnoline fused pyrido benzopyarn – 2- ones as potent antitubercular agents by microplate alamar blue assay method (MABA) presented  in 55th Indian Pharmaceutical Congress, Chennai, during December 2003.
  Phytochemical and cytotoxicity studies on the leaves of Coccinia grandis Linn.,presented  in 55th Indian Pharmaceutical Congress, Chennai, during December 2003.
  Ramalingam,P., Babu Rao,Ch., Ravi, T.K. and Jessy Agestine., Comparitive Anti microbial study of Some Newly Synthasized 2-Azatidinones and 4-Thiazolidinones of Nalidixic acid, presented  in 56th Indian Pharmaceutical Congress, Kolkata, during 13th  -15th December 2004.
  Cheimanipulation  approch at Pharmacophore of Nalidixic acid by Michael addition, presented  in 57th Indian Pharmaceutical Congress, Hyderabad , during 13th  -15th December 2005.
  A molecular manipulation  approach at Pharmacophore of Nalidixic acid by Michael addition, presented  in 58th Indian Pharmaceutical Congress, Mumbai, December 2006.
  SAR Study: Impact of Hydrazides, Hydrazones and Sulfonamido Side chain on invitro antimicrobial and antitubercular activity of Quinoxalines, presented  in 59th Indian Pharmaceutical Congress, varanasi, December  20-23rd , 2007.
  Antitubercular activity of some newly synthesized triazolo (4,3b) cinnoline fused benzo pyran-2- ones. Presented at International convention of APTI held at College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, India, during October 2-3, 2004.
  Qualitative determination of Thalidomide using RP-HPLC Int. Journal of chemical Sciences,5(2),2007,743-748.
  Qualitative determination of Nevirapine in Pharmaceutical dosage forms by RP-HPLC Int. Journal of chemical sciences,6(1),2008,417-421.
  Antimicrobial activity of seeds of Abrus precatorius Linn Asian Journal of chemistry, Vol.21,No.2(2009),1630-1632
  Spectrophotometric Estimation of Ofloxacin in Pure and Pharmaceutical Dosage Forms Asian Journal of chemistry, Vol.21,No.3(2009),2473-2475
  Evaluation of Anti-Inflammatory activity of Acalypha Indica The Indian Pharmacist-Vol.VII,No.75,89-91.
  Permeation studies of Glipizide from Ficus caria fruit mucilage matrices for transdermal delivery  Biomed -4(1) Jan-Mar 2009, pp 70-75.
  Fabrication and evaluation of Aloe barbadensis Miller mucilage based sustained release matrix  Tablets of Glipizide. Biomed -4(2) April-June 2009, pp 192-197.
  Fabrication and evaluation of Aloe barbadensis Miller mucilage based sustained release matrix Tablets of Glimepiride. Asian Journal of Chemistry,Vol.21.No.8(2009),6271-6276.
  Synthesis and Antimicrobial Evaluation of Dibenzo (B,E) Azepin-5,10-(1H) Diones/ 10-substituted Dibenzo (B,E) Azepines.   International Journal of Pharmaceutical Research and Development – Online.
  Spectrophotometric method for the Evaluation of Glimepiride in bulk and pharmaceutical  Formulations. Internatinal journal of Chemical Sciences, 7(3), 2009,1624-1628.
  Preliminary phyotochemical investigation and cytotoxicity studies on the roots of Coccinia grandis linn. – Paper presented during 61st IPC, Ahmedabad.
  Synthesis and antimicrobial evaluation of Dibenzo (B,E) azepin-5,10-(1H)Diones/10-substituted dibenzo (B,E) azepines - Paper presented during 61st IPC, Ahmedabad.
  Review: Polymers in colon drug targeting.      Indian Drugs, 47(3),March 2010,5-13.
  Effect of Leucas aspera on Lead Acetate Induced Nephrotoxicity in Rats,     Asian Journal of Chemistry, vol.22,No.3(2010),2450-2452.
  Vitro Protein Binding Study of Ciprofloxacin by New UV-Spectrophotometric Method.      International Journal of Pharm Tech Research, vol.2,No.2,pp1150-1154.
  In vitro antitubercular and antimicrobial activity of 1- substituted quinoxaline–2, 3(1H, 4H)–diones. Bioorganic & Medicinal chemistry letter accepted –BMCL -14973)
  Synthesis And Antimicrobial Evaluation Of  Dibenzo (b,e ) Azepin - 5, 10 - (1h)Diones/   10 - Substituted  Dibenzo (b,e) Azepines, Int. journal. Pharm research and development, Volume - 1 / Issue - 9 / Article No - 11 (online).
  Cheimanipulation approch at Pharmacophore of Nalidixic acid by Michael addition, Acta ciencia indica (International Journal of Physical Sciences). XXXI C, No.3, 129 (2005).
  Synthesis of some new coumarino [4,3-b]pyrido [6,5-c] cinnolines as potent antitubercular agents, Indian journal of Heterocyclic chemistry (International Journal), vol.15, April – June,  P.no . 359 – 362, (2006).
  A Molecular manipulation approach at Pharmacophore of Nalidixic acid., Acta ciencia indica (International Journal of Physical Sciences). XXXII C, No.4, 335 (2006).
  Comparative Study on oral and Transdermal Administration of ditiazem Hydrochloride in Rabbits., The Pharma Review., Aug’ - 149-151, (2006).
  Impact of 4-Thiazolidinones and 2-Azetidinones on Antimicrobial spectrum of Nalidixic acid., Acta ciencia indica (International Journal of Physical Sciences). XXXII C, No.4, 433 (2006).
  Synthesis and Anti Microbial evaluation of Some Schiff bases of 4-Oxo-Quinolino(2,3-c) Pyridines., Acta ciencia indica (International Journal of Physical Sciences). XXXII C, No.4, 363 (2006).
  Simultaneous Spectrometric Estimation and validation of Cefixime and ornidazole in bulk and pharmaceutical dosage forms by absorbance ratio method (Q – Analysis) Acta ciencia indica (International Journal of Physical Sciences). XXXIII C, No.3, 267 (2007).
  Visible Spectroscopic Estimation and validation of Cefpodoxime proxetil in Bulk and Pharmaceutical Dosage Forms., Asian Journal of Chemistry. Vol.20, No.5(2008), 3373 – 3376.
  Visible Spectroscopic Estimation and validation of Ornidazole in Bulk and Pharmaceutical Dosage Forms., Asian Journal of Chemistry. Vol.20, No. 5 (2008), 3377 – 3380.
  Spectrophotometric Determination and validation of Cefriaxone sodium in bulk and pharmaceutical dosage forms Acta ciencia indica (International Journal of Physical Sciences). XXXIV C, No.3, 547 (2008).
  Spectrophotometric Determination and validation of Sparfloxacin in bulk and pharmaceutical dosage forms Acta ciencia indica (International Journal of Physical Sciences). XXXIV C, No.3, 423 (2008).
  Spectrophotometric Determination and validation of Aceclofenac in bulk and pharmaceutical dosage forms Acta ciencia indica (International Journal of Physical Sciences). XXXIV C, No.3, 447 (2008).
 
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